Tranmere took full advantage of defensive errors to register a seventh home victory which lifted them to second place in League One.
The Merseysiders enjoyed the best of starts with a goal inside 60 seconds. Michael Jackson and Shaun Barker were involved in a defensive mix up and Steve Davies was able to cross to the far post where Chris Greenacre squeezed in his seventh goal of the season.
Keith Southern, Keigan Parker and Wes Hoolahan enjoyed no luck for the Seasiders before Tranmere wasted a great chance to double their lead after half-an-hour. Blackpool keeper Rhys Evans missed a cross by John Thompson but Gareth Taylor headed onto the top of the net.
David Fox headed wide for Blackpool and then a penalty appeal was turned down after Parker appeared to be tripped by Ian Goodison.
It was end to end in the second half but with few goal chances. Andy Morrell did bring a diving save from home keeper Gavin Ward before Tranmere doubled their lead in the 67th minute. The unhappy Evans failed to hold onto a cross by Taylor and Chris Shuker was able to set up Davis for his first goal of the season.
Blackpool kept working hard but Hoolahan, after a fine solo effort, saw his shot saved by Ward.
Then Ward turned aside a Morrell effort in the 90th minute after Taylor had seen a shot blocked on the line at the other end.
Goodison was excellent for Tranmere and there were also busy displays from Davies and Thompson.
Adrian Forbes and Hoolahan worked tirelessly for Blackpool but little went right for them on the night.